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Why Single-Cell Analysis?

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Every cell contains the same DNA—but in each, only certain genes are expressed at same time. Traditionally we study this phenomenon using bulk RNA sequencing, but that approach doesn’t yield the highest resolution—or the clearest results. That’s why Professor of Biostatistics Mingyao Li, PhD, decided to devote herself to sequencing single cells—a field only 10 years old that was named Science magazine’s 2018 technology Breakthrough of the Year.

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