Introduction to HiChIP Technology
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The Dovetail HiChIP MNase Kit combines the benefits of ChIP-seq with the long-range information of
Hi-C, enabling genome-wide mapping of protein-directed topological features. Compared to ChIP-seq, Dovetail HiChIP not only identifies locally-bound sequences, it also captures distal interactions, up to megabases away, mediated by your protein of interest (e.g. promoter/enhancer interactions).
The Dovetail HiChIP MNase Kit uniquely offers the following benefits:
1. Use of MNase unveils topological features down to mono-nucleosome level, enabling the highest resolution mapping of chromatin interactions
2. Simple and reproducible workflow – no sonication required
3. Deeper understanding of protein function – capture ChIP-seq and Hi-C data in a single library
For ease of adoption, Dovetail has validated 8 commonly-used antibodies, with more on the way. The Dovetail HiChIP MNase Kit is the first commercially available product for analyzing protein-directed chromatin architecture.
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