Contraction and Relaxation of Smooth Muscle | Physiology A

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When a stimulus acts on reticular receptors via a G-protein it activates and release IP3 that releases Ca2+.

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Major Ca2+ influx takes place through ligand-gated and voltage-gated Ca2+-channels.This intracellular Ca2+ than binds to protein Calmodulin and together activate myosin light chain kinase.

Activated myosin bind to the actin chain and cause contraction.

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